#bioinformatics #crispr #sg-rna #sequencing

geopagg

An implementation of the geopagg algorithm for p-value aggregation of sgRNAs across gene groupings

12 releases

0.2.9 Oct 4, 2024
0.2.8 Oct 3, 2024
0.2.7 Sep 6, 2024
0.1.3 Aug 12, 2024

#7 in #crispr

46 downloads per month
Used in crispr_screen

MIT license

32KB
629 lines

geopagg

Geometric p-value aggregation for gene-groups


lib.rs:

GeoPAGG: Geometric P-Value Aggregation for Gene Groups

This library implements the GeoPAGG algorithm, which is used for analyzing sgRNA differential abundance data by aggregating p-values and log fold changes across multiple sgRNAs targeting the same gene.

The main components of this library are:

  • GeoPAGG: The main algorithm implementation
  • WeightConfig: Configuration for p-value weighting schemes
  • TransformConfig: Configuration for p-value transformation methods
  • GeoPAGGResults: Structure to hold and display the results

Dependencies

~4.5MB
~82K SLoC