#crispr #bioinformatics #sequencing #sg-rna

intc

An implementation of the *-INC method to calculate an empirical FDR for non-targeting controls in CRISPR screens

10 releases

0.3.3 May 22, 2023
0.3.2 May 22, 2023
0.2.1 May 17, 2023
0.1.4 Feb 2, 2023

#217 in Biology

Download history 48/week @ 2023-02-15 7/week @ 2023-02-22 2/week @ 2023-03-01 4/week @ 2023-03-08 12/week @ 2023-03-15 2/week @ 2023-03-22 6/week @ 2023-03-29 3/week @ 2023-04-05 14/week @ 2023-04-12 7/week @ 2023-04-19 11/week @ 2023-04-26 32/week @ 2023-05-03 106/week @ 2023-05-10 214/week @ 2023-05-17 25/week @ 2023-05-24 25/week @ 2023-05-31

395 downloads per month
Used in crispr_screen

MIT license

45KB
1K SLoC

intc

Including Non-Targeting Controls

This is a library to perform mann-whitney U tests to aggregate sgRNA enrichment p-values at the gene-level and calculate an empirical false discovery rate via bootstrapping of pseudo-genes composed of non-targeting controls.

Dependencies

~6.5MB
~120K SLoC