#crispr #bioinformatics #sequencing #sg-rna #screen

intc

An implementation of the *-INC method to calculate an empirical FDR for non-targeting controls in CRISPR screens

13 releases

0.3.6 Oct 7, 2024
0.3.5 Sep 6, 2024
0.3.3 May 22, 2023
0.2.1 May 17, 2023
0.1.4 Feb 2, 2023

#345 in Biology

23 downloads per month
Used in crispr_screen

MIT license

45KB
1K SLoC

intc

Including Non-Targeting Controls

This is a library to perform mann-whitney U tests to aggregate sgRNA enrichment p-values at the gene-level and calculate an empirical false discovery rate via bootstrapping of pseudo-genes composed of non-targeting controls.

Dependencies

~10MB
~186K SLoC