solana-instruction is used at run time in 9 crates (of which 1 optionally). It is a direct run-time dependency in 6 crates.

Depender (with downloads and own rev deps) solana-instruction version
340 solana-bincode =0.0.2
220 3 solana-program-error =0.0.2
220 solana-serialize-utils =0.0.2
130 solana-stable-layout =0.0.2
solana-transaction-error =0.0.2
100 solana-account optional =0.0.2