#model-checking #symbolic #systems-biology #hctl #boolean-network

bin+lib biodivine-hctl-model-checker

Library for symbolic HCTL model checking on partially defined Boolean networks

12 releases

0.3.1 Nov 7, 2024
0.3.0 Jul 5, 2024
0.2.2 Dec 19, 2023
0.2.0 Sep 22, 2023
0.1.0 Dec 22, 2022

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Symbolic model checker for logic HCTL written in RUST

This repository contains the Rust implementation of the symbolic model checker for hybrid logic HCTL. The method is focused on the analysis of (partially specified) Boolean networks. In particular, it allows to check for any behavioural hypotheses expressible in HCTL on large, non-trivial networks. This includes properties like stability, bi-stability, attractors, or oscillatory behaviour.

Prerequisites

To run the model checker, you will need the Rust compiler. We recommend following the instructions on rustlang.org.

If you are not familiar with Rust, there are also Python bindings for most of the important functionality in AEON.py.

Functionality

This repository encompasses the CLI model-checking tool, and the model-checking library.

Model-checking tool

Given a (partially defined) Boolean network model and HCTL formulae (encoding properties we want to check), the tool computes all the states of the network (and corresponding parametrizations) that satisfy the formula. Currently, there is only a command-line interface, with a GUI soon to be implemented. Depending on the mode, the program can generate BDDs encoding the resulting states and parametrizations, it can print the numbers of satisfying states and colours, or print all the satisfying assignments.

To directly invoke the model checker, compile the code using

cargo build --release

and then run the binary:

.\target\release\hctl-model-checker <MODEL_PATH> <FORMULAE_PATH>
  • MODEL_PATH is a path to a file with BN model in selected format (see below, aeon is default)
  • FORMULAE_PATH is path to a file with a set of valid HCTL formulae (one per line)

We support the following optional arguments:

  • -o <OUTPUT_BUNDLE> - A path to generate a zip bundle with resulting BDDs.
  • -e <EXTENDED_CONTEXT> - A path to an input zip bundle with BDDs specifying context of wild-cards (only relevant for extended formulae).
  • -p <PRINT_OPTION> - An amount of information printed - one of no-print/summary/with-progress/exhaustive.
  • -h or --help for more information

Library

This package also offers an API for utilizing the model-checking functionality. The most relevant high-level functionality can be found in modules analysis and model_checking. Further, useful functionality and structures regarding parsing (parser, tokenizer, syntactic trees) is in preprocessing module.

Model formats

The model checker takes BN models in aeon format as its default input, with many example models present in the benchmark_models directory. However, you can also use SBML and boolnet models.

HCTL formulae

The file with HCTL properties must contain one formula in a correct format per line. The formulae must not contain free variables.

The format is illustrated on benchmark_formulae.txt containing several important formulae.

To create custom formulae, you can use any HCTL operators and many derived ones. We use the following syntax:

  • constants: true/True/1, false/False/0
  • propositions: alphanumeric characters and underscores (e.g. p_1)
  • variables: alphanumeric characters and underscores enclosed in "{}" (e.g. {x_1})
  • negation: ~
  • boolean binary operators: &, |, =>, <=>, ^
  • temporal unary operators: AX, EX, AF, EF, AG, EG
  • temporal binary operators: AU, EU, AW, EW
  • hybrid operators
    • bind x: !{x}:
    • jump x: @{x}:
    • exists x: 3{x}:
    • forall x: V{x}:
  • parentheses: (, )

We also allow to specify the hybrid operators using their names (prefixed by backslash): \bind, \jump, \exists, \forall. You can use this syntax to write a formula like \bind {x}: AG EF {x}. Note that the default for serialization is the short format above.

The operator precedence is following (the lower, the stronger):

  • unary operators (negation + temporal): 1
  • binary temporal operators: 2
  • boolean binary operators: and=3, xor=4, or=5, imp=6, eq=7
  • hybrid operators: 8

However, it is strongly recommended to use parentheses wherever possible to prevent any parsing issues.

Extended formulae

Wild-card propositions

The library also provides functions to model check "extended" formulae that contain so called "wild-card propositions". These special propositions are evaluated as an arbitrary (coloured) set of states provided by the user. This allows the re-use of already pre-computed results in subsequent computations. In formulae, the syntax of these propositions is %property_name%.

Restricting domains of quantified variables

You can also directly restrict a domain of any quantified variable in a following manner:

  • !{x} in %domain%:

The domain is treated similar as a "wild-card proposition" (see above). During the computation, the user provides an arbitrary set of states that will be used as the domain for the variable (the variable may only take the value of states from that set).

This way the user can directly restrict the domain of every {x} encountered during bottom-up computation (makes formula more readable and speeds up the computation).

The following equivalences hold:

  • !{x} in %A%: phi = !{x}: %A% & phi
  • 3{x} in %A%: @{x}: phi = 3{x}: @{x}: %A% & phi
  • V{x} in %A%: @{x}: phi = V{x}: @{x}: %A% => phi

Dependencies

~11–20MB
~249K SLoC