Welcome to MortalSim, a discreet event simulation library for biological systems. It aims to provide a layered, highly modular engine for realistic, scalable simulations of living entities powered by research-based physiological models.

Motivation

Existing physiological simulation solutions are very complex, computationally expensive, and/or difficult to understand and modify.

There is need for an adaptable software solution to provide efficient determination of overall, high-level physiological state which can make good use of existing, clinically verified models.

Goals

• Provide validated physiological events at the organism level
• Support parallel organism simulations in real time with minimal impact to computing resources
• Modular architecture - relatively easy integration and customization
• Support combinations of widely varying model approaches
• Make model addition / removal as easy as possible

Potential Uses

• Epidemiological research & simulation
• Medical / Military training software
• Personalized health insights
• Gaming
• ...

How?

MortalSim operates under the principle that, like ogres and onions, all living organisms can be modeled as a set of biological layers. These layers provide a unique framework within which each component can communicate and interact with other simulation components.

MortalSim currently has the following layers:

• Core
  • Event subscription & dispatch.
• Circulation
  • Closed circulatory system definition.
  • Blood substance interactions with BloodStores.
• Digestion
  • Ingestion, handoff, and elimination.
  • Consumable substance interactions.
• Nervous
  • Nervous system tree definition
  • Nerve-bound Event signaling

Discrete Event Simulation

Mortalsim is centered around discrete Events. At the top level, the progression of events provides the target simulation output, whether that's concious level, heart rate, or any other vital sign.

Key physiological events are provided by the core MortalSim framework, but individual components can define their own custom Events as well.

This was selected for the following reasons:

• Simple
  • Meets the target focus of high-level overall state
  • Event driven states are easily understood and implemented
• Fast
  • Requires minimal computational resources
  • Built to be parallelizable from the ground up
• Flexible
  • Loose coupling between modules
  • Easy manipulation of system inputs and outputs

Roadmap

Core Functionality

Base

• Event Trait & Framework
• Substances Enums
• Substance Stores
• Time Manager
• Sim Component Traits & Framework
• Sim Component Registry
• Layer Manager Traits & Framework

Core Layer

• Core Initializer & Connector
• Core Layer Logic

Circulation Layer

• Blood Vessel Traits & Framework
• Circulation Initializer & Connector
• Circulation Layer Logic

Digestion Layer

• Consumable Traits & Framework
• Digestion Initializer & Connector
• Digestion Layer Logic

Nervous Layer

• Nerve Traits & Framework
• Nerve Signal Traits & Framework
• Nervous Initializer & Connector
• Nervous Layer Logic

Sim

• Layer Processor
• Sim & Organism Traits & Framework
• Sample Sim

Basic Modules

• Human Sim
• Simple Blood Flow
• Cardiovascular Hemodynamics Component (IN PROGRESS)
• Respiration Component
• Brain Consciousness Component
• Kidney Component
• Liver Component
• Digestion Component(s)
• BMR Component
• Acute Injury Component(s)
• Chronic Illness Component(s)
• Musculoskeletal Components

Module Development Tools

• Math routines crate
• SBML to MortalSim component tool (IN PROGRESS)
• Test Harness for Core Components
• Test Harness for Circulation Components
• Test Harness for Digestion Components
• Test Harness for Nervous Components

Language Support

• Python Bindings
• JavaScript Bindings
• C++ Bindings
• Java Bindings