ChaCha20Poly1305 is used at run time in 10 crates (of which 1 optionally). It is a direct run-time dependency in 2 crates.

Depender (with downloads and own rev deps) ChaCha20Poly1305 version
4.9K 2 bip324 ^0.1.1
200 1 easy_secp256k1 ^0.1.1